Metabolic
MOTS-c price comparison
Mitochondrial-derived peptide. Prices from 53 vendors, all normalized to price per mg so a 5 mg and a 20 mg vial can be compared fairly.
Lowest price right now
$1.30
per mg · S1 Research (Step One Ventures)
66% below the median
Compare all 133 offers ↓What the research says about MOTS-c
Evidence map →Evidence base
StrongMultiple human RCTs
Several randomized controlled trials in humans, often summarized by meta-analyses.
- 265
- Papers
- 4
- RCTs
- 5
- Reg. trials
MOTS-c is made by the body. Many human studies measure natural blood levels rather than giving MOTS-c, so the grade overstates research on supplementation.
Where the research comes from
- Human clinical studies: 9
- Animal / lab only: 54
- Other (reviews, untagged): 202
- Meta-analyses / systematic reviews: 1
Key studies
- Systematic reviewMitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review — Physiology international, 2026
- Randomized trialRepeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization — Medicine and science in sports and exercise, 2025
- Randomized trialCirculating levels of MOTS-c in patients with breast cancer treated with metformin — Aging, 2022
- Randomized trialAcute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans — Journal of applied physiology (Bethesda, Md. : 1985), 2021
- Randomized trialEffect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors — Scientific reports, 2021
- Clinical trialβ-Amyloid and mitochondrial-derived peptide-c are additive predictors of adverse outcome to high-on-treatment platelet reactivity in type 2 diabetics with revascularized coronary artery disease — Journal of thrombosis and thrombolysis, 2020
Registered clinical trials (5)
- Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation — recruiting · na
- MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity — recruiting · phase2
- The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination — recruiting
- Cohort Of DEafness-gene Screening — active not recruiting
- Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD — unknown
The grade reflects how much and what kind of research exists — not whether MOTS-c works or is safe. It is computed from PubMed study-type tags and ClinicalTrials.gov registrations as of Oct 22, 2026. Research use only; not medical advice.
Compound Knowledge Base
Research & Pharmacokinetic Specs
Mechanism of Action
Mitochondrial-derived 16-amino-acid peptide encoded in the 12S rRNA region; activates AMPK, regulates sphingolipid and folate-methionine metabolism, and improves cellular glucose uptake.
Target Receptors & Pathways
AMP-activated protein kinase (AMPK) signaling cascade
Half-Life
~4 hours
Storage & Handling
Lyophilized powder at -20°C. Once reconstituted, refrigerate at 2–8°C and use within 14–21 days.
Scientific & Risk Flags
- •Almost all mechanistic and functional evidence is derived from rodent models and cell culture
- •High synthetic cost and variable third-party purity in research markets
- •Added to WADA prohibited list under metabolic modulators
Cheapest MOTS-c by vial size
The lowest price at each size, across all vendors. Tap a size for the full ranking.
Where every vendor sits
Each dot is a vendor’s cheapest in-stock MOTS-c vial, in $ per mg. The spread between the leftmost dot and the median is what shopping around is worth.
Compare every MOTS-c offer
Form
Size
Best $/mg
$1.30
S1 Research (Step One Ventures)
Lowest price
$22.00
S1 Research (Step One Ventures) · 10 mg vial
Median $/mg
$4.50
92 offers match
| Product | Size | Link to vendor | |||
|---|---|---|---|---|---|
| Protide Health United States MOTS-c — 40mg COA CLAIMED | MOTS-c — 40mg | 40 mg vial | $195.00 | $4.88 | View ↗ |
| Protide Health United States MOTS-c — 20mg COA CLAIMED | MOTS-c — 20mg | 20 mg vial | $110.00 | $5.50 | View ↗ |
| Protide Health United States MOTS-c — 10mg COA CLAIMED | MOTS-c — 10mg | 10 mg vial | $65.00 | $6.50 | View ↗ |
| S1 Research (Step One Ventures) MOTS-C — 40mg COA CLAIMED | MOTS-C — 40mg | 40 mg vial | $52.00 | $1.30best | View ↗ |
| Peptide Hub United States MOTS-c — 40mg COA CLAIMED | MOTS-c — 40mg | 40 mg vial | $72.00 | $1.80 | View ↗ |
| Bio Pepz United States MOTS-C 40mg TESTED 81% · 4 | MOTS-C 40mg | 40 mg vial | $79.20 | $1.98 | View ↗ |
| Lab Rat Peptide United States Mots C — 40MG TESTED 76% · 2 | Mots C — 40MG | 40 mg vial | $85.00 | $2.13 | View ↗ |
| S1 Research (Step One Ventures) MOTS-C — 10mg COA CLAIMED | MOTS-C — 10mg | 10 mg vial | $22.00 | $2.20 | View ↗ |
| Zenith Biopeptides United States Mots-c 40mg COA CLAIMED | Mots-c 40mg | 40 mg vial | $90.00 | $2.25 | View ↗ |
| The Naughty Needle United States MOTS-C — 40mg TESTED 80% · 2 | MOTS-C — 40mg | 40 mg vial | $95.00 | $2.38 | View ↗ |
| Atomik Labz United States MOTS-C – 40mg NO COA FOUNDTESTED 69% · 44 | MOTS-C – 40mg | 40 mg vial | $99.00 | $2.48 | View ↗ |
| Eros Peptides United States MOTS-C 20MG COA CLAIMEDTESTED 77% · 3 | MOTS-C 20MG | 20 mg vial | $49.99 | $2.50 | View ↗ |
| Tide Labs United Kingdom MOTS-c — 20 mg COA CLAIMED | MOTS-c — 20 mg | 20 mg vial | $49.99 | $2.50 | View ↗ |
| Umbrella Labs United States MOTS-C PEPTIDE 10MG/40MG VIAL — 40 Milligrams Vial COA CLAIMED | MOTS-C PEPTIDE 10MG/40MG VIAL — 40 Milligrams Vial | 40 mg vial | $99.99 | $2.50 | View ↗ |
| Imperial Peptides UK United Kingdom MOTS-C 10mg COA CLAIMED | MOTS-C 10mg | 10 mg vial | $25.99 | $2.60 | View ↗ |
| Modern Aminos United States MOTS-C — 40MG COA CLAIMEDTESTED 79% · 6 | MOTS-C — 40MG | 40 mg vial | $104.00 | $2.60 | View ↗ |
| Alpha Pro Peptides United States MOTS-C (40mg) COA CLAIMED | MOTS-C (40mg) | 40 mg vial | $104.99 | $2.62 | View ↗ |
| Purus Peptides United States MOTS-c 10mg & 40mg — 40mg COA CLAIMED | MOTS-c 10mg & 40mg — 40mg | 40 mg vial | $105.00 | $2.63 | View ↗ |
| Bio Pepz United States MOTS-C 10MG TESTED 81% · 4 | MOTS-C 10MG | 10 mg vial | $26.40 | $2.64 | View ↗ |
| Tide Labs United Kingdom MOTS-c — 10 mg COA CLAIMED | MOTS-c — 10 mg | 10 mg vial | $27.49 | $2.75 | View ↗ |
| Paramount Peptides United States MOTS-c (50mg) COA CLAIMEDTESTED 65% · 65 | MOTS-c (50mg) | 50 mg vial | $138.13 | $2.76 | View ↗ |
| Glacier Aminos United States MOTS-C — 20mg COA CLAIMED | MOTS-C — 20mg | 20 mg vial | $55.99 | $2.80 | View ↗ |
| Northline Labs United States MOTS-C – Premium Research Peptide — 40mg COA CLAIMED | MOTS-C – Premium Research Peptide — 40mg | 40 mg vial | $116.99 | $2.92 | View ↗ |
| Glacier Aminos United States MOTS-C — 10mg COA CLAIMED | MOTS-C — 10mg | 10 mg vial | $32.19 | $3.22 | View ↗ |
| Based Research United States MOTS-c — 40 mg COA CLAIMED | MOTS-c — 40 mg | 40 mg vial | $130.00 | $3.25 | View ↗ |
| Lux Synth Aminos United States MOTS-C 20mg COA CLAIMED | MOTS-C 20mg | 20 mg vial | $65.00 | $3.25 | View ↗ |
| Oasis Labs United States MOTS-C — : 40mg COA CLAIMED | MOTS-C — : 40mg | 40 mg vial | $132.00 | $3.30 | View ↗ |
| Modified Aminos United States MOTS-c 10mg — Single Vial COA CLAIMED | MOTS-c 10mg — Single Vial | 10 mg vial | $34.95 | $3.50 | View ↗ |
| Modified Aminos United States MOTS-c 20mg — Single Vial COA CLAIMED | MOTS-c 20mg — Single Vial | 20 mg vial | $69.99 | $3.50 | View ↗ |
| Licensed Peptides United States MOTS-C — 40mg 1 pack COA CLAIMED | MOTS-C — 40mg 1 pack | 40 mg vial | $139.99 | $3.50 | View ↗ |
| Amino USA United States MOTS-C 40mg COA CLAIMEDTESTED 32% · 3 | MOTS-C 40mg | 40 mg vial | $140.00 | $3.50 | View ↗ |
| Honest Peptide United States MOTS-C — 10mg COA CLAIMED | MOTS-C — 10mg | 10 mg vial | $35.00 | $3.50 | View ↗ |
| Zenith Biopeptides United States Mots-c 10MG COA CLAIMED | Mots-c 10MG | 10 mg vial | $35.00 | $3.50 | View ↗ |
| Eros Peptides United States MOTS-C 10MG COA CLAIMEDTESTED 77% · 3 | MOTS-C 10MG | 10 mg vial | $35.99 | $3.60 | View ↗ |
| Drexa Labs United States MOTS-c — 20mg COA CLAIMED | MOTS-c — 20mg | 20 mg vial | $72.00 | $3.60 | View ↗ |
| Peptide Crafters United States MOTS-c (15mg) COA CLAIMEDTESTED 61% · 60 | MOTS-c (15mg) | 15 mg vial | $55.00 | $3.67 | View ↗ |
| Accelerate Labs United States MOTS-c 10MG COA CLAIMEDTESTED 65% · 20 | MOTS-c 10MG | 10 mg vial | $37.99 | $3.80 | View ↗ |
| PSPeptides United States MOTS-C (1 Vial) — 50MG COA CLAIMED | MOTS-C (1 Vial) — 50MG | 50 mg vial | $189.99 | $3.80 | View ↗ |
| Verified Peptides United States MOTS C — 20mg COA CLAIMEDTESTED 65% · 39 | MOTS C — 20mg | 20 mg vial | $77.00 | $3.85 | View ↗ |
| Verified Peptides United States MOTS-C Peptide (20MG) — 20mg COA CLAIMEDTESTED 65% · 39 | MOTS-C Peptide (20MG) — 20mg | 20 mg vial | $77.00 | $3.85 | View ↗ |
| Atomik Labz United States MOTS-C – 10mg NO COA FOUNDTESTED 69% · 44 | MOTS-C – 10mg | 10 mg vial | $39.00 | $3.90 | View ↗ |
| Modern Aminos United States MOTS-C — 10MG COA CLAIMEDTESTED 79% · 6 | MOTS-C — 10MG | 10 mg vial | $39.00 | $3.90 | View ↗ |
| Lux Synth Aminos United States MOTS-c 10mg COA CLAIMED | MOTS-c 10mg | 10 mg vial | $39.99 | $4.00 | View ↗ |
| Certified Peptides United States MOTS C 40MG COA CLAIMEDTESTED 60% · 13 | MOTS C 40MG | 40 mg vial | $160.00 | $4.00 | View ↗ |
| Drexa Labs United States MOTS-c — 10mg COA CLAIMED | MOTS-c — 10mg | 10 mg vial | $40.00 | $4.00 | View ↗ |
| Peptide Hub United States MOTS-c — 10mg COA CLAIMED | MOTS-c — 10mg | 10 mg vial | $40.00 | $4.00 | View ↗ |
| Purus Peptides United States MOTS-c 10mg & 40mg — 10mg COA CLAIMED | MOTS-c 10mg & 40mg — 10mg | 10 mg vial | $40.00 | $4.00 | View ↗ |
| YourFitnessPeptides United States MOTS-c 10mg COA CLAIMED | MOTS-c 10mg | 10 mg vial | $41.43 | $4.14 | View ↗ |
| YourFitnessPeptides United States MOTS-c 40mg COA CLAIMED | MOTS-c 40mg | 40 mg vial | $170.00 | $4.25 | View ↗ |
| Alpha Pro Peptides United States MOTS-C (10mg) COA CLAIMED | MOTS-C (10mg) | 10 mg vial | $44.99 | $4.50 | View ↗ |
| FRO Peptides United States MOTS-C – Research Peptide (10mg) — 10mg COA CLAIMED | MOTS-C – Research Peptide (10mg) — 10mg | 10 mg vial | $44.99 | $4.50 | View ↗ |
| Certified Peptides United States MOTS C 20MG COA CLAIMEDTESTED 60% · 13 | MOTS C 20MG | 20 mg vial | $90.00 | $4.50 | View ↗ |
| AminoVault United States MOTS-c — 40 MG US Sourced COA CLAIMED | MOTS-c — 40 MG US Sourced | 40 mg vial | $192.00 | $4.80 | View ↗ |
| Oasis Labs United States MOTS-C — : 10mg COA CLAIMED | MOTS-C — : 10mg | 10 mg vial | $48.50 | $4.85 | View ↗ |
| Direct Peptides United States MOTS-c — 10mg 1 Vial NO COA FOUNDTESTED 76% · 2 | MOTS-c — 10mg 1 Vial | 10 mg vial | $49.00 | $4.90 | View ↗ |
| Penguin Peptides United States MOTS-c — 40 mg TESTED 73% · 9 | MOTS-c — 40 mg | 40 mg vial | $197.00 | $4.92 | View ↗ |
| PureChems Europe (country not stated) MOTS-c - 10mg COA CLAIMED | MOTS-c - 10mg | 10 mg vial | $49.99 | $5.00 | View ↗ |
| Umbrella Labs United States MOTS-C PEPTIDE 10MG/40MG VIAL — 10 Milligrams Vial COA CLAIMED | MOTS-C PEPTIDE 10MG/40MG VIAL — 10 Milligrams Vial | 10 mg vial | $49.99 | $5.00 | View ↗ |
| Amino USA United States MOTS-C 10mg COA CLAIMEDTESTED 32% · 3 | MOTS-C 10mg | 10 mg vial | $50.00 | $5.00 | View ↗ |
| Masters Peptides (M-Peptides) United States MOTS-c — 40mg COA CLAIMED | MOTS-c — 40mg | 40 mg vial | $200.00 | $5.00 | View ↗ |
| Prime Lab Peptides United States MOTS-C – 10mg COA CLAIMED | MOTS-C – 10mg | 10 mg vial | $50.00 | $5.00 | View ↗ |
| EZ Peptides United States MOTS-C 10mg COA CLAIMED | MOTS-C 10mg | 10 mg vial | $54.00 | $5.40 | View ↗ |
| Ameano Peptides United States MOTS-c 10mg COA CLAIMEDTESTED 66% · 12 | MOTS-c 10mg | 10 mg vial | $54.00 | $5.40 | View ↗ |
| AminoVault United States MOTS-c — 10 MG US Sourced COA CLAIMED | MOTS-c — 10 MG US Sourced | 10 mg vial | $54.00 | $5.40 | View ↗ |
| Sigma Peptides United States MOTS-C 10MG TESTED 73% · 3 | MOTS-C 10MG | 10 mg vial | $54.98 | $5.50 | View ↗ |
| Penguin Peptides United States MOTS-c — 20 mg TESTED 73% · 9 | MOTS-c — 20 mg | 20 mg vial | $110.00 | $5.50 | View ↗ |
| Polaris Peptides United States MOTS-C 10mg NO COA FOUNDTESTED 64% · 107 | MOTS-C 10mg | 10 mg vial | $55.00 | $5.50 | View ↗ |
| Paramount Peptides United States MOTS-c (10mg) COA CLAIMEDTESTED 65% · 65 | MOTS-c (10mg) | 10 mg vial | $55.25 | $5.53 | View ↗ |
| Certified Peptides United States MOTS C 10MG COA CLAIMEDTESTED 60% · 13 | MOTS C 10MG | 10 mg vial | $58.00 | $5.80 | View ↗ |
| JD BioWorks United States MOTS-C — 10 mg COA CLAIMED | MOTS-C — 10 mg | 10 mg vial | $59.84 | $5.98 | View ↗ |
| Lab Rat Peptide United States Mots C — 10MG TESTED 76% · 2 | Mots C — 10MG | 10 mg vial | $59.99 | $6.00 | View ↗ |
| Ascension Peptides United States MOTS-C (10MG) COA CLAIMED | MOTS-C (10MG) | 10 mg vial | $62.00 | $6.20 | View ↗ |
| Penguin Peptides United States MOTS-c — 10 mg TESTED 73% · 9 | MOTS-c — 10 mg | 10 mg vial | $65.00 | $6.50 | View ↗ |
| PSPeptides United States MOTS-C (1 Vial) — 10MG COA CLAIMED | MOTS-C (1 Vial) — 10MG | 10 mg vial | $69.99 | $7.00 | View ↗ |
| Warrior Makers United States MOTS-C — 40MG COA CLAIMED | MOTS-C — 40MG | 40 mg vial | $299.00 | $7.47 | View ↗ |
| Northline Labs United States MOTS-C – Premium Research Peptide — 10mg COA CLAIMED | MOTS-C – Premium Research Peptide — 10mg | 10 mg vial | $76.49 | $7.65 | View ↗ |
| Licensed Peptides United States MOTS-C — 10mg 1 pack COA CLAIMED | MOTS-C — 10mg 1 pack | 10 mg vial | $76.99 | $7.70 | View ↗ |
| HkRoids United States MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 40mg/vial TESTED 60% · 82 | MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 40mg/vial | 40 mg vial | $314.00 | $7.85 | View ↗ |
| HkRoids United States MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 20mg/vial TESTED 60% · 82 | MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 20mg/vial | 20 mg vial | $157.00 | $7.85 | View ↗ |
| HkRoids United States MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 30mg/vial TESTED 60% · 82 | MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 30mg/vial | 30 mg vial | $236.00 | $7.87 | View ↗ |
| HkRoids United States MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 10mg/vial TESTED 60% · 82 | MOTS-C Peptide | Mitochondrial-Derived Peptide for Metabolic Research — 1kit 10mg/vial | 10 mg vial | $79.00 | $7.90 | View ↗ |
| ResearchChemical.com United States MOTS-c 10mg COA CLAIMED | MOTS-c 10mg | 10 mg vial | $79.99 | $8.00 | View ↗ |
| Warrior Makers United States MOTS-C — 20MG COA CLAIMED | MOTS-C — 20MG | 20 mg vial | $165.00 | $8.25 | View ↗ |
| Based Research United States MOTS-c — 10 mg COA CLAIMED | MOTS-c — 10 mg | 10 mg vial | $90.00 | $9.00 | View ↗ |
| Warrior Makers United States MOTS-C — 10MG COA CLAIMED | MOTS-C — 10MG | 10 mg vial | $94.00 | $9.40 | View ↗ |
| Peptide Pros United States MOTS-C 5mg COA CLAIMED | MOTS-C 5mg | 5 mg vial | $47.25 | $9.45 | View ↗ |
| Biotech Peptides United States MOTS-c (10mg) COA CLAIMED | MOTS-c (10mg) | 10 mg vial | $99.00 | $9.90 | View ↗ |
| BioLongevity Labs United States MOTS-c (10mg) COA CLAIMEDTESTED 71% · 34 | MOTS-c (10mg) | 10 mg vial | $109.97 | $11.00 | View ↗ |
| Core Peptides United States MOTS-C – 10MG COA CLAIMED | MOTS-C – 10MG | 10 mg vial | $116.00 | $11.60 | View ↗ |
| AminoVault United States MOTS-c — 10 MG US cGMP COA CLAIMED | MOTS-c — 10 MG US cGMP | 10 mg vial | $119.00 | $11.90 | View ↗ |
| ResearchChemical.com United States MOTS-c 5mg COA CLAIMED | MOTS-c 5mg | 5 mg vial | $59.99 | $12.00 | View ↗ |
| Sports Technology Labs United States MOTS-c 5 mg COA CLAIMED | MOTS-c 5 mg | 5 mg vial | $59.99 | $12.00 | View ↗ |
Already bought MOTS-c?
Find out in 5 seconds whether you overpaid — and share your result.
MOTS-c pricing FAQ
What is the cheapest MOTS-c right now?
S1 Research (Step One Ventures) currently lists MOTS-c at $1.30 per mg (MOTS-C — 40mg, $52.00), the lowest of the 53 vendors we compare. The median is $3.80 per mg, so shopping around can save a lot.
How much does MOTS-c cost per mg?
Across 53 vendors, injectable MOTS-c ranges from $1.30 to $12.00 per mg, with a median of $3.80. Larger vials generally cost less per mg, which is why we normalize every listing to a price per milligram.
How much does a 10 mg vial of MOTS-c cost?
A 10 mg vial of MOTS-c costs between $22.00 and $116.00 across 47 vendors, with a median of $50.00. The cheapest is S1 Research (Step One Ventures) at $22.00.
Which MOTS-c vendors publish a COA?
50 of the 62 vendors listing MOTS-c say they publish certificates of analysis (COAs). A COA is the vendor’s own claim and can be copied or re-dated, so we also show independent test ratings (Finnrick) on each vendor page where they exist, and let you filter to “COA claimed” vendors.
Is there human research on MOTS-c?
PubMed lists 265 papers on MOTS-c: 4 randomized controlled trials, 9 human clinical studies and 54 animal or lab-only studies, plus 5 registered clinical trials. We grade the evidence base as “Strong”: Several randomized controlled trials in humans, often summarized by meta-analyses. This describes how much research exists, not whether it works.
Is MOTS-c legal and safe to use?
MOTS-c is sold for laboratory research use only. PeptideComps compares prices and does not give medical advice, and we can’t vouch for any product’s quality or legality — check the rules where you live.